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Indoor cats can be quite independant and take care of themselves for short periods of time. However, all cats do need some sort of human interaction to keep their stress levels at a manageable level.
Most experts agree that cats can be left alone, without any type of sitter, for 2-3 days. Make certain that they have a constant source of fresh water, and a crunchy food dispenser that will stay full that long. Also give your kitty plenty of things to do to help with the boredom of being alone.
Be sure to give Kitty a treat or two when you get home.